L-Arginine Monohydrochloride (2025)

L-Arginine Monohydrochloride - Names and Identifiers

L-Arginine Monohydrochloride - Physico-chemical Properties

L-Arginine Monohydrochloride - Risk and Safety

L-Arginine Monohydrochloride - Upstream Downstream Industry

L-Arginine Monohydrochloride - Reference

L-Arginine Monohydrochloride - Nature

Open Data Verified Data

• This product is white crystalline powder; Odorless; Bitter taste. Soluble in water, aqueous solution acidic reaction. Very slightly dissolved in ethanol. The decomposition temperature is 23 5 deg C.
• This product is the hydrochloride of L-arginine. Arginine is a semi-essential amino acid that is less synthesized in the human body and needs to be partially supplemented from food. In the body it is an intermediate metabolite of ornithine cycle, can promote the production and excretion of urea, correct ammonia poisoning and can relieve hepatic coma. Arginine is the main component of sperm protein, and also has the function of promoting sperm production and providing sperm movement energy. In nature, it widely exists in pig hair, hoof nails, blood meal, gelatin, protamine, small miscellaneous fish. Due to the strong alkalinity of arginine aqueous solution, it absorbs carbon dioxide from the air and is made into hydrochloride.

Last Update：2024-01-02 23:10:35

L-Arginine Monohydrochloride - Preparation Method

Open Data Verified Data

1. hydrolysis method.
2. fermentation method.

Last Update：2022-01-01 11:10:14

L-Arginine Monohydrochloride - Standard

Authoritative Data Verified Data

This product is L-2-amino -5-guanidopentanoic acid hydrochloride. Calculated as dry product, containing C6H14N402 • HC1 should be not less than 98.5%.

Last Update：2024-01-02 23:10:35

L-Arginine Monohydrochloride - Trait

Authoritative Data Verified Data

• This product is white or off-white crystalline powder.
• This product is soluble in water, very slightly soluble in ethanol.

specific rotation

take this product, precision weighing, add 6mol /L hydrochloric acid solution to dissolve and quantitatively dilute to make a solution containing about 80mg per lml, and determine according to law (General 0621 ), the specific rotation was 21.5 ° to 23.5 °.

Last Update：2022-01-01 15:35:37See Alsocalculate the ph of 00110 m solution of arginine hydrochloride arginine hcl harg arginine has pk values of 1823 pkal 8991 pka2 and 1201 pka3 ph 213 calculate the concentration of each specie 75026Arginine·HCl › Buffer Solutions and Reagents›Electrophoresis › SERVA Electrophoresis GmbH

L-Arginine Monohydrochloride - Introduction

Nitric oxide synthase substrate, which can be converted to citrulline and NO. Insulin secretion is induced by a NO-dependent mechanism.

Last Update：2022-10-16 17:12:08

L-Arginine Monohydrochloride - Use

Open Data Verified Data

• amino acid drugs. It is an important component of amino acid infusion and comprehensive amino acid preparation, and can be used as a nutritional supplement.
• usage and dosage for treatment of hepatic coma, decreasing blood ammonia: 15~20g each time, diluted with 5% glucose looml, and then dropped within 4 hours: arginine equivalent to 48mmol hydrochloric acid per lOg; Treatment of male infertility: Oral 4g daily, three months for a course of treatment.

Last Update：2022-01-01 11:10:15

L-Arginine Monohydrochloride - Differential diagnosis

Authoritative Data Verified Data

1. appropriate amounts of the product and the arginine reference product were dissolved and diluted with water to prepare a solution containing about 0.4mg per 1 ml as the test solution and the reference solution. According to the chromatographic condition test under other amino acids, the position and color of the main spot of the test solution should be the same as that of the reference solution.
2. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 406).

Last Update：2022-01-01 15:35:37

L-Arginine Monohydrochloride - Safety

Open Data Verified Data

• healthy person once intravenous drip of this product 30g or liver insufficiency patients intravenous drip 30g, can be tolerated, no side effects. Intravenous drip too fast can cause salivation, Vomit, facial flushing and so on. Hyperchloremic acidosis can be caused by high-dose infusion. Anuria or renal dysfunction in patients with caution or contraindication.
• closed storage.

Last Update：2022-01-01 11:10:15

L-Arginine Monohydrochloride - Exam

Authoritative Data Verified Data

transmittance of solution

Take lg of this product, Add 10ml of water to dissolve, according to ultraviolet-visible spectrophotometry (General rule 0401 ), measure the transmittance at 430nm wavelength, not less than 98.0%.

sulfate

take 0.5g of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.02% of standard potassium sulfate solution, it should not be more concentrated ().

phosphate

take 0.4g of this product, place it in the crucible, add 0.3g of magnesium nitrate and 5ml of water, put it in a water bath and evaporate to dryness, burn it with small fire until it is completely ash, add 5ml of water and 3ml of sulfuric acid solution (1- 4), slowly heat for 5 minutes, heat 10ml of water, filter, put the filtrate in a colorimetric tube, and wash the filter residue with an appropriate amount of hot water, add ammonium molybdate solution [take ammonium molybdate 0.5g, add sulfuric acid solution (3-100) 10ml to dissolve] and phosphorus test solution 1ml each, heat at 60°C for 10 minutes, such as blue, with standard phosphate solution (precision weigh 0.143g of potassium dihydrogen phosphate, put in 1000ml measuring flask, add appropriate amount of water to dissolve and dilute to the scale) 0.02% ml of control solution prepared by the same method should not be deeper ().

ammonium salt

take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 0.02% of standard ammonium chloride solution, it shall not be deeper ().

Protein

Take lg of this product, Add 10ml of water to dissolve, add 5 drops of 20% trichloroacetic acid solution, and no precipitation is allowed.

other amino acids

take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 10 mg per lml as a test solution; Take 1ml for precision measurement and put it in a 500ml measuring flask, dilute to scale with water, shake, as a control solution; Take the appropriate amount of arginine and lysine hydrochloride in the same flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, Draw 5 u1 of each of the above three solutions, respectively point on the same silica gel G thin layer plate, with N-propanol-concentrated ammonia solution (2:1) as the developing solvent, expand, dry, spray with ninhydrin in acetone solution (1- 50 ), and heat at 105°C until spots appear, and examine immediately. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. The test solution should not have more than one impurity spot, and the color should not be deeper (0.2%) than the main spot of the control solution.

loss on drying

take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).

ignition residue

not more than 0.1% (General rule 0841).

Iron Salt

take 2.0g of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.001% of standard iron solution, it should not be deeper ().

Heavy metals

take 2.0g of this product, add 23ml of water and 2ml of acetate buffer (pH 3.5) to dissolve, and check according to law (General rule 0821 first law), containing heavy metals shall not exceed 10 parts per million.

arsenic salt

take 2.0g of this product, add 23ml of water to dissolve, add hydrochloric acid 5mU to check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).

pyrogen

take this product, add Sterile Water for Injection dissolved and diluted to make a solution containing 50mg per lml, check according to law (General rule 1142), dose according to rabbit body weight per lkg injection 10ml, should comply with the regulations. (For injection)

chlorine content

take about 0.35g of this product, precision weighing, add 20ml of water to dissolve, add 2ml of dilute acetic acid and 8~10 drops of bromophenol blue indicator solution, and use silver nitrate titration solution (0.lmol/ L) titrated to blue-purple. Each 1 ml of silver nitrate titration solution (0.1 mol /L) corresponds to 3.545mg of C1. The chlorine content shall be 16.5%-17.1% based on the dry product.

Last Update：2022-01-01 15:35:38

L-Arginine Monohydrochloride - Content determination

Authoritative Data Verified Data

take this product about O.lg, precision weighing, add anhydrous formic acid 3ml to dissolve, add glacial acetic acid 50ml and Mercury acetate test solution 6ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol /L) titration, and the results of the titration were corrected with a blank test. Each 1 ml perchloric acid titration solution (0.1 mol /L) corresponds to 10.53mg of C6H14N402. HCl.

Last Update：2022-01-01 15:35:39

L-Arginine Monohydrochloride - Category

Authoritative Data Verified Data

amino acid drugs.

Last Update：2022-01-01 15:35:39

L-Arginine Monohydrochloride - Storage

Authoritative Data Verified Data

sealed storage.

Last Update：2022-01-01 15:35:39

L-Arginine Monohydrochloride - Arginine hydrochloride tablets

Authoritative Data Verified Data

This product contains Arginine hydrochloride (C6H14N402 • HCl) should be labeled the amount of 90.0% to 110.0%.

trait

This product is white or off-white.

identification

1. take an appropriate amount of fine powder of this product (equivalent to 0.5g of Arginine hydrochloride), add 5ml of water, stir to dissolve Arginine hydrochloride, filter, take 1ml of filtrate, add naphthol solution (take "-naphthol g, 10% sodium hydroxide solution (0.2ml) and sodium hypobromate solution (0.5ml of bromine and 20ml of 5% sodium hydroxide solution) were added to dissolve, respectively.
2. an appropriate amount of the filtrate under identification (1) was taken and diluted with water to prepare a solution containing about 0.4mg of Arginine hydrochloride per 1 ml as a test solution. The same results should be shown in the identification (1) Test under Arginine hydrochloride.
3. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
4. The filtrate test under identification (1) should show the identification reaction of chloride (General rule 0301).
5. two items (2) and (3) above can be selected as one item.

examination

should be in accordance with the relevant provisions under The tablet item (General rule 0101).

Content determination

• an appropriate amino acid analysis method or high performance liquid chromatography (General 0512) is used for the measurement.
• chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; With 0.05mol /L acetate buffer (pH 6.4)- 50% acetonitrile solution (65:35) as mobile phase; the detection wavelength was 362nm. The number of theoretical plates shall not be less than 3000 calculated as arginine peak, and the separation degree between arginine peak and internal standard peak shall meet the requirements.
• preparation of internal standard solution an appropriate amount of alanine was taken, dissolved and diluted with water to prepare a solution containing 0.5mg per 1 ml, and then obtained by shaking.
• determination Method: Take 20 tablets of this product, accurately weigh, grind, accurately weigh an appropriate amount (about equivalent to Arginine hydrochloride lOOmg ), put it in a 100ml measuring flask, add water to dissolve and dilute to the scale, 1ml of filtrate and 1ml of internal standard solution were added to the same 10ml measuring flask, and 0.5mol/ L sodium bicarbonate solution (pH 9.0) was added. 1ml with 1% 2, 4-dinitrofluorophenylacetonitrile solution 150 u1, shake, place in a water bath (60°C ± 2°C) in the dark for 60 minutes, remove, cool, dilute to the scale with phosphate buffer (pH 7.0), shake well, as a test solution, accurately take 10ul into the liquid chromatograph, record the chromatogram. An appropriate amount of arginine reference substance was accurately weighed, dissolved with water and quantitatively diluted to prepare a solution containing 0.8mg per 1ml as a reference solution. Take 1ml of each of the reference solution and the internal standard solution for precise measurement, place them in the same 10ml measuring flask, and operate with the same method. The content of Arginine hydrochloride (C6H14N402 • HCl) in the test product was calculated by the peak area according to the internal standard method, and the result was multiplied by 1.209.

category

Same as Arginine hydrochloride.

specification

0.25g

storage

sealed and stored in a dry place.

Last Update：2022-01-01 15:35:40

L-Arginine Monohydrochloride - Arginine hydrochloride injection

Authoritative Data Verified Data

This product is a sterile aqueous solution of Arginine hydrochloride. The content of Arginine hydrochloride (C6H14N402 • HCl) shall be between 95.0% and 105.0% of the labeled amount.

trait

This product is colorless and clear liquid.

identification

1. take this product, add ninhydrin about 2mg, heat, the solution showed blue purple.
2. an appropriate amount of this product is diluted with water to prepare a solution containing about 0.4mg of Arginine hydrochloride per 1 ml as a test solution. The same results should be shown in the identification (1) Test under Arginine hydrochloride.

examination

• the pH value should be 3.0 to 5.0 (General 0631).
• pyrogen to take this product, according to the law (General rule 1142), the dose of rabbit body weight per lkg slowly injected 5ml, should comply with the provisions.
• others should comply with the relevant provisions under injection (General 0102).

Content determination

take 10ml of this product, put it in a 100ml measuring flask, dilute it to the scale with hydrochloric acid solution (6-10), shake it well, and determine the optical rotation according to law (General rule 0621 ), the Weight (g) of the test product containing Arginine hydrochloride (C6H14N402. HCl) is obtained by multiplying by 4.444.

category

Same as Arginine hydrochloride.

specification

20ml:5g

storage

sealed storage.

Last Update：2022-01-01 15:35:41

L-Arginine Monohydrochloride - Reference Information

Last Update：2024-04-09 21:21:28